Publications

Designing a Small Fluorescent Inhibitor to Investigate Soluble Epoxide Hydrolase Engagement in Living Cells. S Brunst, J Schoenfeld, P Breunig, LD Burgers, M DeMeglio, JHM Ehrler, FF Lillich, L Weizel, JK Hefendehl, R Fuerst, E Proshak, K Heisinger. ACS Medical Chemistry Letters, July 2022

Microglia Phenotypes Converge in Aging and Neurodegenerative Disease. M. Candlish and JK Hefendehl. Frontiers in Neurology May 2021

Medin aggregation causes cerebrovascular dysfunction in aging wild-type mice. K. Degenhardt, J Wagner, A Skodras, M Candlish, AJ Koppelmann, K Wild, R Maxwell, C Rotermund, F von Zweydorf, CJ Gloeckner, HA Davies, J Madine, D Del Turco, R Feederle, T Lashley, TDeller, P Kahle, J K Hefendehl, M Jucker, and JJ Neher. PNAS Sep. 2020

Neurovascular interaction in the nervous system, Volume 35,
M. Segarra, M. R. Aburto, J.K Hefendehl and A. Acker-Palmer. Annual Review of Cell and Developmental Biology Oct. 2019

Long-term in vivo imaging of individual microglia cells A.A. Skodras, J.K. Hefendehl and J.J. Neher. Methods in Molecular Biology August 2019

Nanoscale Surveillance of the Brain by Microglia via cAMP-Regulated Filopodia. Bernier LP, Bohlen CJ, York EM, Choi HB, Kamyabi A, Dissing-Olesen L, Hefendehl JK, Collins HY, Stevens B., Barris B, MacVicar BA. Cell Reports Vol 27, Issue 10, 4 June 2019

Microglia turnover with aging and in an Alzheimer’s model via long-term in vivo single-cell imaging. P. Füger, J.K. Hefendehl, C. Schlosser, A.C.Wendeln, U.Obermüller, J.J.Neher, P. Martus, S. Kohsaka, S. Sisodia, M. Thunemann, R. Feil, A. Skodras, M.Jucker, Nature Neurosi 28 August 2017

Mapping synaptic glutamate transporter dysfunction in vivo to regions surrounding Aβ plaques by iGluSnFR Two- Photon imaging. JK. Hefendehl, J. LeDue, R. Ko, T. Murphy, B.A. MacVicar. Nature Comm Oct 2016

Activation of neuronal NMDA receptors triggers transient ATP-medated microglial process outgrowth. Dissing-Olesen L, LeDue J, Rungta R, Hefendehl JK, Choi H, and MacVicar B. J Neurosci. 2014

Homeostatic and injury-induced microglia behavior in the aging brain. Hefendehl JK, Neher JJ, Sühs RB, Kohsaka S, Skodras A, and Jucker M. Aging Cell 2013 Aug 16; pp1–10

Comment on “ApoE-Directed Therapeutics Rapidly Clear b-Amyloid and Reverse Deficits in AD Mouse Models”. Veeraraghavalu K,* Zhang C,* Miller S,* Hefendehl JK,* Rajapaksha TW,* Ulrich J,* Jucker M, Holtzman DM, Tanzi RE , Vassar R, Sisodia SS. (shared first authorship). Science 2013 Jan 22 340, 924 (2013)

Long-term in vivo Imaging of β-Amyloid Plaque Appearance and Growth in a Mouse Model of Cerebral β-Amyloidosis. Hefendehl JK*, Wegenast-Braun BM*, Liebig C, Eicke D, Milford D, Calhoun ME, Eichner M, Jucker M.. J Neurosci. 2011 Jan 12;31(2):624-9.

Repeatable target localization for long-term in vivo imaging of mice with mulitphoton microscopy. J.K. Hefendehl, Milford D.K., Eicke D., Grathwohl S.A., Wegenast-Braun B.M., Calhoun M.E.,Jucker M., and Liebig C. Journal of Neuroscience Methods, 205 (2011) 357-363.

Modeling familial Danish dementia in mice supports the concept of the amyloid hypothesis of Alzheimer’s disease. Coomaraswamy J, Kilger E, Wölfing H, Schäfer C, Kaeser SA, Wegenast-Braun BM, Hefendehl JK, Wolburg H, Mazzella M, Ghiso J, Goedert M, Akiyama H, Garcia-Sierra F, Wolfer DP, Mathews PM, Jucker M. PNAS 2010 Apr 27;107(17):7969-74.