Lab Members

Jasmin Hefendehl

Principle Investigator

The main focus of my research is the early phase of Alzheimer’s Disease and its impact on cell function in the neurovascular unit. Using models of comorbidity we are particularly interested in basic research with a direct link to a potential therapeutical application

E-mail: Hefendehl@bio.uni-frankfurt.de

Phone: +49(0)69 798 42528

Peter Breunig

PhD Student

For my Bachelors, I studied Biosciences at the Ruprecht- Karls University in Heidelberg. I continued my studies at the University in Heidelberg with a Masters in Molecular Bioscience- Major Neuroscience and completed my Master Thesis “Effects of exogenic stressors on endogenous tau protein phosphorylation in hiPSC derived neurons” at the BioMedX innovation center. To complete my studies, I moved to Frankfurt where I investigate molecular alterations in pericytes in the comorbidity of Alzheimer’s Disease (AD) and Vascular Cognitive Impairment (VCI). I will use primary culture and co- culture methods to analyze possible changes in the pericytes way of interacting with the amyloid- beta (Aβ) protein and the cells Aβ clearing capacity both in vitro and in vivo.

E-mail: breunig@bio.uni-frankfurt.de

Phone: +49(0)69 798 42523

Michael J. Candlish

Postdoctoral Fellow

I completed my bachelor’s and master’s degrees in pharmacology and biomedical sciences, respectively. I then undertook research  focused on unraveling the diverse physiological roles of kisspeptin for my doctoral degree (Dr. rer. nat.). In my current position as a postdoctoral researcher in the neurovascular disorders group, I use two-photon microscopy to dissect the long-term interactions and mechanisms underlying the comorbidity between cerebrovascular pathology and Alzheimer’s disease.

E-mail: Candlish@bio.uni-frankfurt.de

Phone: +49(0)69 798 42523

Jan Hofmann

PhD Student

In humans 90% of all Alzheimer’s disease patients show a co-occurrence with some kind of cerebrovascular impairment, such as stroke or small vessel disease. Pericytes which line blood vessels in the brain are known to be involved in both diseases. These cells will be analysed for changes in gene expression levels using single cell RNA-sequencing. This shall clarify how pericytes are involved in both diseases in order to potentially identify novel therapeutic targets and disease markers.

E-mail: jan.hofmann@bio.uni-frankfurt.de

Phone: +49(0)69 798 42523

Eloah De Biasi

PhD Student

E-mail: elobiasi@bio.uni-frankfurt.de

Phone: +49(0)69 798 42523

Joshua Bowman-Köhler

MSc Student

I completed my bachelor’s degree at the Albert-Ludwigs-University in Freiburg and have now moved to Frankfurt to continue my higher education with a master’s degree in Interdisciplinary Neuroscience. For my master’s thesis project, I joined the lab of Dr. Hefendehl, and hope to further our understanding of the interaction between Alzheimer’s diasease and vascular disorders. In my research, I will focus on cerebral amyloid angiopathy in a diet-based mouse model. Additionally, I will investigate the effects of hypoxia on pericytes in culture.

E-mail: j.koehler@stud.uni-frankfurt.de

Phone: +49(0)69 798 42523

Murphy DeMeglio

MSc Student

I completed my Bachelor of Science in Psychology at the University of Georgia with a focus on biological psychology. I am currently pursuing a Master of Neuroscience from Oldenburg University. I joined the Hefendehl group for my thesis project, where I will investigate the role of lipid mediators in pericyte detachment and migration in Alzheimer’s Disease. 

E-mail: murphy.demeglio@uni-oldenburg.de

Phone: +49(0)69 798 42523